Berahyaluronidase alfa (ALT-B4) is a hyaluronidase variant. Berahyaluronidase alfa is a fusion protein targeting Hyaluronidase PH-20, Sperm surface protein PH-20, HYAL3, Sperm adhesion molecule 1, PH20, SPAM1, Hyal-PH20, Hyaluronoglucosaminidase PH-20. Berahyaluronidase alfa can be used in the study of advanced and metastatic solid tumors.