FLI-06 is an inhibitor of Notch signaling with an EC50 of 2.3 μM.
IC50&Target
EC50: 2.3 μM (Notch signaling)
体外研究
FLI-06, disrupted the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A. FLI-06 inhibited general secretion at a step before exit from the endoplasmic reticulum. In FLI-06–treated cells, no APPCTF accumulates despite strongly reduced Aβ secretion, suggesting that it acts upstream of α-secretase and β-secretase cleavage. FLI-06 is a very useful chemical probe to study the inhibition of membrane traffic at pre- ER-exit site (ERES) stages without fusion of ER-Golgi.
分子式
C25H30N2O5
分子量
438.52
CAS号
313967-18-9
运输条件
Room temperature in continental US; may vary elsewhere.