ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs.
IC50&Target
DYRK
体外研究
ID-8 (0.1-10 μM) increases human embryonic stem cell (hESC) survival.
ID-8 (10 μM) stimulates ESCs proliferation in serum-free media for more than 1 month.
分子式
C16H14N2O4
分子量
298.29
CAS号
147591-46-6
运输条件
Room temperature in continental US; may vary elsewhere.