S-adenosylmethione depends on magnesium to transfer methyl from S-adenosylmethionine to the hydroxyl group on dopamine, converting it to 3-methoxytyramine.S-adenosylmethione is found in two forms in tissues, the soluble form (S-COMT) and the membrane-bound form (MB-COMT).S-adenosylmethione is used to regulate adrenaline and noradrenaline levels in the brain. S-adenosylmethione is used to regulate adrenaline, norepinephrine, and dopamine levels in the brain.