Tauro-β-muricholic acid sodium - CAS:145022-92-0

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Tauro-β-muricholic acid sodium (Synonyms:T-βMCA sodium)

目录号 : KM10592 CAS No. : 145022-92-0 纯度 : ≥95%

Data Sheet 产品使用指南

Tauro-β-muricholic Acid sodium (T-βMCA sodium) 是一种内源性代谢物，是一种竞争性、可逆的 FXR 拮抗剂，其 IC₅₀ 值为 40 μM。

规格	价格	是否有货	数量
1mg		In-stock

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生物活性

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC₅₀ of 40 μM.

体外研究

T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC₅₀ ~10 μM).
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells.
T-βMCA sodium induces proliferation and DNA damage in Lgr5 cells.

体内研究

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression.
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17.

Animal Model:	APCmin/+ mice
Dosage:	400 mg/kg
Administration:	Oral gavage; twice a week; for 6 weeks
Result:	Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.

分子式

C₂₆H₄₄NNaO₇S

分子量

537.68

CAS号

145022-92-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8598 mL	9.2992 mL	18.5984 mL
5 mM	0.3720 mL	1.8598 mL	3.7197 mL
10 mM	0.1860 mL	0.9299 mL	1.8598 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： ≥95%