BpV(HOpic) - CAS:722494-26-0

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BpV(HOpic)

目录号 : KM10538 CAS No. : 722494-26-0 纯度 : ≥95%

Data Sheet 产品使用指南

BpV(HOpic) 是一种有效的和选择性的 PTEN 抑制剂，IC₅₀ 值为 14 nM。Nanocarrier-BpV(HOpic) 具有神经保护作用。

规格	价格	是否有货	数量
5mg		In-stock

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Other Forms of Rapamycin:

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Isoginkgetin In-stock
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Ginkgolic Acid In-stock
Propargyl-PEG4-amine In-stock

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生物活性

BpV(HOpic) is a potent and selective inhibitor of PTEN with an IC₅₀ of 14 nM. Nanocarrier-BpV(HOpic) has neuroprotective activity.

体外研究

BpV(HOpic) (1 µM) treatment increases cell proliferation and decreases apoptotic rate in MG63 cells received Cisplatin treatment.
Bpv(HOpic) (1 µM) enhances migration of C2C12 myoblasts and is associated with activation of PI3K/AKT and MAPK/ERK signalling pathways.
BpV(HOpic) (1 µM; 48 hours) promotes the initiation of swine follicle growth and development, similar as in rodent species and humans.
Nanocarrier-BpV(HOpic) enhances axonal outgrowth of neurons.

体内研究

BpV(HOpic) (0.05 mg/kg; i.p.) at reperfusion ameliorates liver ischemia/reperfusion (I/R) injury in vivo.
BpV(HOpic) (200 μg/kg; i.p.) exacerbates renal dysfunction and promotes tubular damage in mice with ischemia/reperfusion injury (IRI).

Animal Model:	Male Wistar rats are subjected to partial hepatic ischemia
Dosage:	0.05 mg/kg
Administration:	I.p. injections at the start of reperfusion
Result:	Ameliorated reoxygenation injury and reproduced the hepatoprotective effects obtained by adenosine A2A receptor stimulation.

Animal Model:	Male C57BL/6 mice (8-12 weeks old; 20-30 g ) are subjected to renal ischemia
Dosage:	200 μg/kg
Administration:	I.p. injections 1 h before ischemia and then administers every 6 h after ischemia for 24 hr
Result:	Raised the level of serum creatinine and blood serum urea nitrogen.

分子式

C₆H₇K₂NO₈V

分子量

347.24

CAS号

722494-26-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 125 mg/mL (359.98 mM; Need ultrasonic)

DMSO : 2.89 mg/mL (8.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8799 mL	14.3993 mL	28.7985 mL
5 mM	0.5760 mL	2.8799 mL	5.7597 mL
10 mM	0.2880 mL	1.4399 mL	2.8799 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

科研文献

•Cancer Cell Int. 2021 Dec 19;21(1):689.

纯度： ≥95%

Data Sheet

产品使用指南

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 1 篇科研文献

The molarity calculator equation

The dilution calculator equation