Belvarafenib TFA (HM95573 TFA) 是一种有效的，广泛的迅速加速纤维肉瘤激酶 (RAF) 的抑制剂，其对 B-RAF，B-RAFv600E 和C-RAF 的 IC50 值分别为 56 nM, 7 nM 和 5 nM。
| 生物活性 |
Belvarafenib TFA (HM95573 TFA) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv and C-RAF respectively. |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 体外研究 |
Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively. |
|||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
|||||||||
| 储存方式 |
|
|||||||||
| 临床试验 |
|
纯度： 98%
关注我们
获得KKL MED 最新资讯
客服小K 
客服小K
Data Sheet