SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with Kd values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively.
体外研究
SM-1295 (compound 5) binds to both cIAP1 and cIAP2 proteins with Ki values of <10 nM and displays a selectivity of >900-fold for cIAP1 over XIAP.
SM-1295 (compound 5) exhibits an IC50 of 46 nM in MDA-MB-231.
分子式
C29H36BrN5O4
分子量
598.53
CAS号
1562375-46-5
运输条件
Room temperature in continental US; may vary elsewhere.