Antimycin A1 是泛醇-细胞色素 c 氧化还原酶的特定电子转移 (electron transfer) 抑制剂。Antimycin A1 通过抑制 HIF-1α 激活导致的 VEGF 产生减少来抑制血管生成。
| 生物活性 |
Antimycin A1 is a specific electron transfer inhibitor of ubiquinol-cytochrome c oxidoreductase. Antimycin A1 inhibits angiogenesis through decrease in VEGF production caused by inhibition of HIF-1α activation. |
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| 体外研究 |
Antimycin A, a mixture of Antimycins A1, A2, A3, and A4, is an antibiotic produced by Streptomyces species and displays antifungal, insecticidal, nematocidal, and piscicidal properties. Antimycin A inhibits Bcl-2 and Bcl-xL proteins, inducing apoptosis. |
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| 分子式 |
C28H40N2O9
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| 分子量 |
548.63
|
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| CAS号 |
642-15-9
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 科研文献 |
纯度： ≥98%
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