Dextran sulfate sodium salt (MW 36000-50000) - CAS:9011-18-1

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Dextran sulfate sodium salt (MW 36000-50000) (Synonyms:DSS (MW 36000-50000); DXS (MW 36000-50000)；硫酸葡聚糖钠盐 (36000-50000))

目录号 : KM2314 CAS No. : 9011-18-1

Data Sheet SDS 产品使用指南

Dextran sulfate sodium salt (MW 36000-50000) 作为一种脱水葡萄糖聚合而成的化合物，分子量为36000-50000的DSS凭借其结肠上皮毒性，成为诱导结肠炎的有效工具。根据实验目的调整DSS浓度和给药时间，可建立急性、慢性和急慢性交替性模型，是用于诱发模型动物溃疡性结肠炎最常见和最有效的化学诱导剂之一。DSS还可与AOM（KM8289）联合使用，诱导结肠癌模型。

规格	价格	是否有货	数量
5g		In-stock
25g		In-stock
50g		In-stock
100g		In-stock

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生物活性

Dextran sulfate sodium salt (MW 36000-50000) As a compound formed by the polymerization of dehydrated glucose, DSS with a molecular weight of 36000-50000 has become an effective tool for inducing colitis due to its colonic epithelial toxicity. By adjusting the concentration and administration time of DSS according to the experimental objectives, acute, chronic, and alternating acute chronic models can be established, which is one of the most common and effective chemical inducers for inducing ulcerative colitis in model animals. DSS can also be used in combination with AOM (KM8289) to induce colon cancer models.

体内研究

Dextran sulfate sodium salt (MW 36000-50000) can be used to induce acute/chronic colitis and colitis related colon cancer models.

1、Inducing an acute colitis model

Using daily drinking methods for modeling, 3-5% DSS aqueous solution is added for 7 days and restored with 3 days of drinking water.

2、Chronic colitis

Modeling was conducted using daily drinking methods, with a 1-3% DSS aqueous solution for 5 days followed by a 5-day drinking water recovery period, for a total of three cycles.

Note: Ready to use: DSS solution is easily degradable and should be stored at 4 ° C for no more than 24 hours after preparation. Fresh solution should be replaced daily to avoid contamination.

分子量

36000-50000

CAS号

9011-18-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H2O : ≥ 100 mg/mL

* "≥" means soluble, but saturation unknown

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂：PBS

Solubility: 25 mg/mL (Infinity mM); Clear solution; Need ultrasonic

Data Sheet

SDS

产品使用指南

暂无相关参考文献

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量

浓度

体积

分子量*

重置计算

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

浓度

体积

浓度

体积

重置计算

动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

给药剂量

mg/kg

动物平均体重

每只动物给药体积

动物数量

只

第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

% DMSO

% Tween 80

% ddH₂O

% DMSO

计算重置

计算结果:

工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器