ADS032 是 NLRP1 和 NLRP3 双重抑制剂，能够快速、可逆且稳定地抑制炎性体形成。ADS032 可减少 NLPR1 和 NLRP3 激活人源巨噬细胞和支气管上皮细胞而分泌和成熟的 IL-1β 和 TNF-α，减少 NLRP3 诱导的 ASC 斑点形成。ADS032 可以保护小鼠免受致命的甲型流感病毒，减少肺部炎症并提高其存活率。ADS032 抑制 Nigericin 诱发的 IL-1β 分泌，IC50s 分别为 94.6 μM (No wash out) 和 354 μM (Wash out)。
| 生物活性 |
ADS032 is a dual inhibitor of NLRP1 and NLRP3 that can rapidly, reversibly and stably inhibit inflammasome formation. ADS032 can reduce NLPR1 and NLRP3 activation of human macrophages and bronchial epithelial cells to secrete and mature IL-1β and TNF-α, and reduce NLRP3-induced ASC speck formation. ADS032 protected mice against the deadly influenza A virus, reducing inflammation in the lungs and improving survival. ADS032 inhibits Nigericin -induced IL-1β secretion with IC50s of 94.6 μM (No wash out) and 354 μM (Wash out) respectively. |
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| 分子式 |
C22H29NO4S
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| 分子量 |
403.53
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| CAS号 |
2757333-37-0
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Store at -20˚C |
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| 溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (247.81 mM; Need ultrasonic) Ethanol: 12.5 mg/mL (30.98 mM; ultrasonic and warming and heat to 60°C) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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Data Sheet
