| 生物活性 |
CAY10790 is a cysteinyl leukotriene 1 (CysLT1) receptor antagonist (IC50 = 2.8 µM) and G protein-coupled bile acid receptor 1 (GPBAR1) agonist. It induces receptor transactivation in HEK293T cells expressing human GPBAR1 (EC50 = 3 µM). CAY10790 (10 µM) reduces TNF-α and IL-1β levels in LPS-stimulated RAW 264.7 cells. It also reduces the proliferation of RAW 264.7 cells induced by leukotriene D4 .
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| 分子式 |
C17H13NO3
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| 分子量 |
279.3
|
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| CAS号 |
107813-86-5
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| 中文名称 |
3-(2-quinolinylmethyloxy)benzoic acid
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
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纯度： >95%
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