| 生物活性 |
BMS-903452 is a potent and selective GPR119 agonist with EC50 of 14 nM. BMS-903452 is indicated for the treatment of acute and chronic rodent diabetes. GPR119 was mainly expressed in pancreatic b cells and gastrointestinal endocrine cells. GPR119 had no significant inhibitory effect on 9 different cytochrome P450 enzymes (IC50 > 40 μM), did not activate PXR (EC50>50 μM), and was not toxic to liver (HEPG2) cell lines.
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|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 分子式 |
C21H19Cl2FN4O4S
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| 分子量 |
513.37
|
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| CAS号 |
1339944-47-6
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| 运输条件 |
Room temperature in continental US; may vary elsewhere.
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| 储存方式 |
|
纯度： ≥95%
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