CORM-3 - CAS:475473-26-8

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CORM-3

目录号 : KM9903 CAS No. : 475473-26-8 纯度 : 98%

Data Sheet 产品使用指南

CORM-3 是一种 CO 释放分子，能减弱 NF-κB p65 的核异位，减少 ROS 的生成，并提高细胞内谷胱甘肽和超氧化物歧化酶的水平。CORM-3 可减少 NLRP3 炎症小体的激活

规格	价格	是否有货	数量
1mg		In-stock
5mg		In-stock

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生物活性

CORM-3, a carbon monoxide-releasing molecule, attenuates NF-κB p65 nuclear translocation, reduces ROS generation and enhances intracellular glutathione and superoxide dismutase levels. CORM-3 reduces NLRP3 inflammasome activation.

体外研究

CORM-3 suppresses caspase-1 activation and the secretion of interleukin (IL)-1β and IL-18 in macrophages in response to lipopolysaccharide (LPS) and ATP. CORM-3 inhibits the oligomerization of the adaptor protein apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), which is required for NLRP3-dependent caspase-1 activation.

体内研究

CORM-3 (4 mg/kg, ip) reduces NLRP3 inflammasome activation and inhibits hyperglycemia-induced inflammation in mice.

Animal Model:	WT mice (C57BL/6J male, 8e10 weeks old).
Dosage:	4 mg/kg.
Administration:	IP for 3 h before i.p. injection of E. coli LPS (10 mg/kg), and IP injection after 7-day-treatment of S0130.
Result:	Resulted in significantly lower plasma levels of IL-1β and IL-18 in response to LPS challenge in vivo in WT mice relative to that in vehicle-treated control mice, whereas TNF-a levels were unchanged. Had lower expression of cleaved caspase-1 and cleaved IL-1b in response to ATP and nigericin, relative to vehicle control, whereas the expression of procaspase-1 and pro-IL-1β expression was unchanged.

分子式

C₅H₇NO₅ClRu

分子量

294.61

CAS号

475473-26-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 120 mg/mL (407.32 mM; Need ultrasonic)

H₂O : 50 mg/mL (169.72 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3943 mL	16.9716 mL	33.9432 mL
5 mM	0.6789 mL	3.3943 mL	6.7886 mL
10 mM	0.3394 mL	1.6972 mL	3.3943 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

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