Nanaomycin A 是第一个选择性 DNMT3B 抑制剂，IC50 为 500 nM。Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的抑癌基因。Nanaomycin A 抑制人疟原虫恶性疟原虫的体外生长，IC80 值为 33.1 nM。
| 生物活性 |
Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. |
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| 体外研究 |
Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines. Cell Cytotoxicity Assay
Western Blot Analysis
RT-PCR
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| 分子式 |
C16H14O6
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| 分子量 |
302.28
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| CAS号 |
52934-83-5
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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