CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
| 生物活性 |
CHPG is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. |
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| 体外研究 |
CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment. Cell Viability Assay
Apoptosis Analysis
Western Blot Analysis
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| 体内研究 |
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
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| 分子式 |
C8H8NO3Cl
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| 分子量 |
201.61
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| CAS号 |
170846-74-9
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 溶解性数据 |
In Vitro:
DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble) |
纯度： 98%
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