BB-Cl-Amidine hydrochloride is a peptidylarginine deminase (PAD) inhibitor.
IC50&Target
PAD.
体内研究
Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely.
Animal Model:
MRL/lpr mice.
Dosage:
1 mg/kg.
Administration:
Subcutaneous injection daily from 8 to 14 weeks of age.
Result:
Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.
运输条件
Room temperature in continental US; may vary elsewhere.