GW-803430 - CAS:515141-51-2

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GW-803430 (Synonyms:GW-3430)

目录号 : KM9649 CAS No. : 515141-51-2 纯度 : 98%

Data Sheet 产品使用指南

GW-803430 (GW-3430) 是一种有效的选择性黑色素浓缩激素受体 1 (MCH R1) 拮抗剂，pIC₅₀ 为 9.3。GW-803430 在肥胖动物模型中具有口服活性。

规格	价格	是否有货	数量
5mg		In-stock
10mg		In-stock

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生物活性

GW-803430 (GW-3430) is a potent and selective melanin-concentrating hormone receptor 1 (MCH R1) antagonist with a pIC₅₀ of 9.3. GW-803430 is orally active in an animal model of obesity.

体外研究

GW-803430 demonstrates a potent antagonist activity towards MCH induced MCHR1 receptor with an IC₅₀ value of ~13 nM.

体内研究

GW-803430 (0.3, 3, and 15 mg/kg; oral administration; once daily) causes a sustained dose-dependent weight loss relative to vehicle controls.
GW-803430 is a suitable compound for its good pharmacokinetic properties (bioavailability=31%, t_1/2=11 h) and brain penetration (6:1 brain:plasma concentration) in mice.

Animal Model:	High fat diet-induced obese AKR/J mice
Dosage:	0.3, 3, and 15 mg/kg
Administration:	Orally, qd,12 days
Result:	Caused a sustained dose-dependent weight loss of -6.2%, -12.1%, and -13.1%, respectively, relative to vehicle controls.

分子式

C₂₅H₂₄N₃O₃Scl

分子量

481.99

CAS号

515141-51-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

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