(RS)-AMPA monohydrate - CAS:76463-67-7

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(RS)-AMPA monohydrate (Synonyms:(±-AMPA monohydrate))

目录号 : KM9619 CAS No. : 76463-67-7 纯度 : 98%

Data Sheet 产品使用指南

(RS)-AMPA ((±)-AMPA) monohydrate 是一种谷氨酸类似物，是一种有效的选择性兴奋性神经递质 L-谷氨酸 (L-glutamic acid) 激动剂。(RS)-AMPA monohydrate 不会干扰海藻酸或 NMDA 受体的结合位点。

规格	价格	是否有货
5mg		In-stock
10mg		In-stock
50mg	询价	In-stock
100mg	询价	In-stock

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Other Forms of Rapamycin:

Deudextromethorphan (AVP-786) In-stock
(S)-ATPO In-stock
AMPA receptor antagonist-3 In-stock
(RS)-AMPA In-stock
Tat-NR2Baa In-stock

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生物活性

(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors.

体外研究

(RS)-AMPA monohydrate (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors.

分子式

C₇H₁₂N₂O₅

分子量

204.18

CAS号

76463-67-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

H₂O : 5 mg/mL (24.49 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.8976 mL	24.4882 mL	48.9764 mL
5 mM	0.9795 mL	4.8976 mL	9.7953 mL
10 mM	0.4898 mL	2.4488 mL	4.8976 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%