AEG3482 - CAS:63735-71-7

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AEG3482

目录号 : KM9453 CAS No. : 63735-71-7 纯度 : 98%

Data Sheet 产品使用指南

AEG3482 是一种有效的抗凋亡化合物，可诱导热休克蛋白 70 (HSP70) 的表达来抑制 JNK 活性。AEG3482 通过直接结合 HSP90，从而促进 HSP70 和 HSP25 的 HSF1 依赖性表达。

规格	价格	是否有货	数量
5mg		In-stock

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生物活性

AEG3482 is a potent antiapoptotic compound that inhibits Jun kinase (JNK) activity through induced expression of heat shock protein 70 (HSP70). AEG3482 directly binds HSP90, thereby facilitating HSF1-dependent expression of HSP70 and HSP25.

体外研究

AEG3482 (0.3-30 μM; 2 d) inhibits nerve growth factor (NGF) withdrawal-induced death in SCG neurons, with an EC₅₀ of ∼20 μM.
AEG3482 (1-80 μM; 40 h) inhibits p75NTR- and NRAGE- mediated apoptosis of PC12 cells in a dose-dependent manner.
AEG3482 (10-40 μM; 30 h) inhibits p75NTR- and NRAGE-mediated JNK activation in PC12 cells.

Apoptosis Analysis

Cell Line:	PC12 cells
Concentration:	1, 2.5, 5, 10, 20, 40, 80 μM
Incubation Time:	40 hours
Result:	Reduced p75NTR- or NRAGE-induced cell death by greater than 90% at the concentration of 40 μM. Exerted a slight toxic effect in cells infected with the LacZ control at the concentration of 80 μM.

Western Blot Analysis

Cell Line:	PC12 cells
Concentration:	10, 20, 40 μM
Incubation Time:	30 hours
Result:	Attenuated p75NTR- and NRAGE-induced c-Jun phosphorylation and caspase-3 cleavage, and the levels of c-Jun protein.

分子式

C₁₀H₈N₄O₂S₂

分子量

280.33

CAS号

63735-71-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 28 mg/mL (99.88 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5672 mL	17.8361 mL	35.6722 mL
5 mM	0.7134 mL	3.5672 mL	7.1344 mL
10 mM	0.3567 mL	1.7836 mL	3.5672 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%

Data Sheet

产品使用指南

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Other Forms of Rapamycin:

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