A-286982 是一种有效的变构 LFA-1/ICAM-1 相互作用抑制剂，在 LFA-1/ICAM-1 结合和 LFA-1 介导的细胞粘附试验中，IC50 分别为 44 nM 和 35 nM。
| 生物活性 |
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively. |
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| 体外研究 |
A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site. |
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| 分子式 |
C24H27N3O4S
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| 分子量 |
453.55
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| CAS号 |
280749-17-9
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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纯度： 98%
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