Garcinol - CAS:78824-30-3

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Garcinol (Synonyms:山竹子素)

目录号 : KM9426 CAS No. : 78824-30-3 纯度 : 98%

Data Sheet 产品使用指南

Garcinol 是一种从印度藤黄提取的聚异戊二烯基二苯甲酮，对乙酰胆碱酯酶 (AChE) 和丁酰胆碱酯酶 (BChE) 具有抗胆碱酯酶的特性，IC₅₀ 分别为 0.66 µM 和 7.39 µM。Garcinol 还抑制组蛋白乙酰转移酶 (HATs, IC₅₀=7 μM) 和 p300/CPB 相关因子 (PCAF, IC₅₀=5 μM)。Garcinol 具有抗炎和抗癌活性。

规格	价格	是否有货
1mg		In-stock
5mg		In-stock
10mg	询价	In-stock
50mg	询价	In-stock

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生物活性

Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.

体外研究

Garcinol (10-50 µM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner.
Garcinol (10-50 µM; 24-72 hours) induces apoptosis in HNSCC cells.
Garcinol (50 µM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.

Cell Proliferation Assay

Cell Line:	CAL27 and UMSCC1 cells
Concentration:	10, 25, 50 µM
Incubation Time:	24, 48, and 72 hours
Result:	Inhibited the proliferation of two HNSCC cell lines in a time- and dose-dependent manner.

Apoptosis Analysis

Cell Line:	CAL27 and UMSCC1 cells
Concentration:	10, 25, 50 µM
Incubation Time:	24, 48, and 72 hours
Result:	Induced apoptosis in HNSCC cells.

Western Blot Analysis

Cell Line:	CAL27 cells
Concentration:	50 µM
Incubation Time:	1, 2, 4, 6 hours
Result:	Suppressed phosphorylation and degradation of the constitutive IκBα in a time-dependent manner.

体内研究

Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth.

Animal Model:	Five-week-old athymic nu/nu male mice bearing subcutaneous CAL27 tumors
Dosage:	1 and 2 mg/kg
Administration:	I.p.; five times/week for 4 consecutive weeks
Result:	Induced significant inhibition of tumor growth.

分子式

C₃₈H₅₀O₆

分子量

602.80

CAS号

78824-30-3

中文名称

山竹子素

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 50 mg/mL (82.95 mM; Need ultrasonic)

Ethanol : 20 mg/mL (33.18 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.6589 mL	8.2946 mL	16.5893 mL
5 mM	0.3318 mL	1.6589 mL	3.3179 mL
10 mM	0.1659 mL	0.8295 mL	1.6589 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (4.15 mM); Suspended solution; Need ultrasonic

此方案可获得 2.5 mg/mL (4.15 mM) 的均匀悬浊液，悬浊液可用于口服和腹腔注射。
以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。