(S,R,S)-AHPC TFA
(Synonyms:VHL ligand 1 TFA;VH032-NH2 TFA)
目录号 : KE1471
CAS No. : 1631137-51-3
纯度 : ≥95%
(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
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生物活性 |
(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
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分子式 |
C24H31F3N4O5S
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分子量 |
544.59
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CAS号 |
1631137-51-3
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中文名称 |
VHL ligand 1 TFA;VH032-NH2 TFA
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运输条件 |
Room temperature in continental US; may vary elsewhere.
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储存方式 |
Store at -20˚C
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