Inclisiran - CAS:1639324-58-5

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Inclisiran (Synonyms:ALN-PCSsc)

目录号 : KM9130 CAS No. : 1639324-58-5 纯度 : 98%

Data Sheet 产品使用指南

Inclisiran (ALN-PCSsc) 是一种双链小干扰 RNA (siRNA) 分子，可抑制 PCSK-9 的转录。Inclisiran 可用于高脂血症和心血管疾病 (CVD) 研究。

规格	价格	是否有货	数量
1mg		In-stock
5mg	询价	In-stock

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生物活性

Inclisiran (ALN-PCSsc) is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9. Inclisiran can be used for hyperlipidemia and cardiovascular disease (CVD) research.

IC₅₀&Target

PPARγ IL-1β Caspase-1 NLRP3

体外研究

Inclisiran is a double-stranded small RNA molecule that works by blocking the transcription of proprotein convertase subtilisin kexin 9 (PCSK-9), leading to a reduction of PCSK-9 levels in the hepatocytes, resulting in an increased expression of low-density lipoprotein (LDL) receptors in the hepatocyte membrane and, as a consequence, it reduces the circulating levels of LDL cholesterol (LDL-C).

体内研究

Inclisiran (1-10 mg/kg; intraperitoneal injection; every 20 weeks) inhibits the progression of atherosclerosis and the expression of pyroptosis-related factors in ApoE^-/- mice induced by a high-fat diet.

Animal Model:	Male ApoE^-/- mice (8 weeks old, 17-20 g); high-fat diet (HFD)-induced atherosclerosis model
Dosage:	1, 5, 10 mg/kg (dissolved in PBS)
Administration:	Intraperitoneal injection; 20 weeks
Result:	Significantly reduced LDL-C, TC, TG, and increased HDL-C in plasma. Decreased aortic plaque area and lipid deposition. Decreased pyroptosis-related factors (NLRP3, ASC, GSDMD, IL-1β, IL-18).

CAS号

1639324-58-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

溶解性数据

H2O : 5 mg/mL (0.31 mM; Need ultrasonic)

纯度： 98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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动物实验计算换算器

第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量）

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第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系客服为您提供正确的澄清溶液配方）

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工作液浓度： mg/ml；

DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

配置后的溶液总体积：

注意：1. 首先保证母液是澄清的；
2. 一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。

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The molarity calculator equation

The dilution calculator equation

动物实验计算换算器