BPR1M97 is a dual-acting mu opioid receptor (MOP) and nociceptin-orphanin FQ peptide (NOP) receptor agonist with Ki values of 1.8 and 4.2 nM, respectively. BPR1M97 shows high potency and blood-brain barrier penetration, and produces potent antinociceptive effects.
IC50&Target
Ki: 1.8 nM (MOP), 4.2 nM (NOP)
体内研究
BPR1M97 (1.8 mg/kg; s.c.; once) demonstrates antinociception in a murine model of cancer pain.
Animal Model:
Male wild-type C57BL/6 mice (25-30 g)
Dosage:
1.8 mg/kg
Administration:
Subcutaneous injection (s.c.); once
Result:
Demonstrated antinociception in a murine model of cancer pain.
分子式
C18H18Cl2N2O
分子量
349.25
CAS号
2059904-66-2
运输条件
Room temperature in continental US; may vary elsewhere.