(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research.
IC50&Target
TNF-α
体外研究
(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages.
体内研究
(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction.
Animal Model:
Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant
Dosage:
25 mg/kg, 50 mg/kg
Administration:
Oral gavage; daily; for 3 weeks
Result:
The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
分子式
C16H16N6O
分子量
308.34
CAS号
1333714-43-4
运输条件
Room temperature in continental US; may vary elsewhere.