Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with Ki of 7 nM for hGHS-R1a.
体外研究
Capromorelin stimulates GH release in rat pituitary cell cultures with EC50 of 3 nM.
体内研究
Dogs receiving capromorelin (30 mg/mL) have food consumption that is significantly greater than dogs treated with placebo. All dogs in the capromorelin group gain weight by 0.52 kg, more than that of placebo group. Capromorelin shows enhanced intestinal absorption in rodent models and exhibits superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%, F(dog)=44%]. Capromorelin stimulates GH release in anesthesized rat model, with ED50 of 0.05 mg/kg iv.
分子式
C32H41N5O10
分子量
655.70
CAS号
193273-69-7
中文名称
卡普瑞林酒石酸盐
运输条件
Room temperature in continental US; may vary elsewhere.