ML401, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity.
IC50&Target
IC50: 1.03 nM (EBI2)
体外研究
ML401 shows no toxicity (>50 μM) towards immortalized Fa2-N4 human hepatocytes and non-cytotoxic in MTT in both LnCap and IMR-32 cells (>50 μM).
体内研究
ML401 shows very good stability in both human plasma and mouse plasma.
分子式
C20H20BrClN2O
分子量
419.74
CAS号
1597489-14-9
运输条件
Room temperature in continental US; may vary elsewhere.