Afegostat D-Tartrate 是一种药理学伴侣，高亲和力且特异性和可逆地结合内质网 (ER) 中的酸性 β-葡萄糖苷酶 (GCase)。
| 生物活性 |
Afegostat D-Tartrate is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity. |
|---|---|
| IC50&Target |
GCase |
| 体内研究 |
Vivo: Afegostat (AT2101) increases GCase activity in brain, liver, and spleen. Afegostat (100 mg/kg) administrates orally for 4 months to Thy1-aSyn mice improved motor and nonmotor function, abolishes microglial inflammatory response in the substantia nigra, reduces α-synuclein immunoreactivity in nigral dopaminergic neurons, and reduces the number of small α-synuclein aggregates, while increasing the number of large α-synuclein aggregates.
|
| 分子式 |
C10H19NO9
|
| 分子量 |
297.26
|
| CAS号 |
957230-65-8
|
| 中文名称 |
阿戈司他 D-酒石酸盐
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
-20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| 临床试验 |
|
纯度： 98%
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