Sermorelin is a 29-residue N-terminal analog of growth hormone-releasing hormone (GHRH) that retains the ability to stimulate growth hormone (GH) release. Sermorelin (1 μg/kg, i.v.) increases serum GH levels in rats by approximately 17% compared with saline control after 15 minutes. It also increases GH release in pigs when administered at a dose of 250 ng/kg. Sermorelin (1 μM) increases proliferation of NCI-H727 human bronchial carcinoid cells by 30% and increases vascular endothelial growth factor (VEGF) secretion. It increases phosphorylation of focal adhesion kinase (FAK) and expression of VEGF in A549 lung cancer cells when used at a concentration of 0.1 μM. Formulations containing sermorelin have been used to diagnose and treat growth hormone deficiency.
| 分子式 |
C149H246N44O42S
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| 分子量 |
3357.88
|
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| CAS号 |
86168-78-7
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| 中文名称 |
丝膜来宁
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| 储存方式 |
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纯度： >97%
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