2-Methylthioadenosine diphosphate trisodium - CAS:475193-31-8

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2-Methylthioadenosine diphosphate trisodium (Synonyms:2-Methylthio-ADP trisodium)

目录号 : KM7700 CAS No. : 475193-31-8

Data Sheet 产品使用指南

2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) 是一种有效的嘌呤能 P2Y 受体激动剂，对人 P2Y13、小鼠 P2Y13 和人 P2Y12 的 EC₅₀ 分别为 19、6.2 和 5 nM。2-Methylthioadenosine diphosphate trisodium 对人 P2Y1 和大鼠 P2Y6 的 pEC₅₀ 分别为 8.29 和 5.75。2-Methylthioadenosine diphosphate trisodium 诱导血小板聚集和形态改变，并抑制前列腺素E1作用下血小板内环腺苷酸的积累。

规格	价格	是否有货	数量
5mg		In-stock

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Ginkgolide J In-stock
Ginkgolide K In-stock
THK-5470 In-stock
NH-3 In-stock
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生物活性	2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC₅₀s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC₅₀s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1.
体外研究	2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor.
分子式	C₁₁H₁₆N₅Na₃O₁₁P₂S
分子量	539.24
CAS号	475193-31-8
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Solution, -20°C, 2 years