Rasagiline mesylate - CAS:161735-79-1

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Rasagiline mesylate (Synonyms:甲磺酸雷沙吉兰; (R-AGN1135 mesylate; TVP1012 mesylate))

目录号 : KM7567 CAS No. : 161735-79-1 纯度 : 98%

Data Sheet 产品使用指南

Rasagiline (R-AGN1135) mesylate 是一种高效的不可逆的选择性线粒体单胺氧化酶 (MAO) 抑制剂，抑制大鼠脑 MAO B 和 MAO A 的 IC₅₀ 分别为 4.43 nM 和 412 nM。

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100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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Ginkgolide K In-stock
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NH-3 In-stock
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生物活性

Rasagiline (R-AGN1135) mesylate is a highly potent selective irreversible mitochondrial monoamine oxidase (MAO) inhibitor with IC₅₀s of 4.43 nM and 412 nM for rat brain MAO B and A activity, respectively.

体外研究

Rasagiline (0.25 nM; 96 hours) significantly increases the proliferation rates of SH-SY5Y and 1242-MG upon Dexamethasone (10 µM) treatment.

Cell Viability Assay

Cell Line:	Neuroblastoma SH-SY5Y, and glioblastoma 1242-MG
Concentration:	0.25 nM
Incubation Time:	96 hours
Result:	Caused ~60% increase in the cell proliferation rate for SH-SY5Y cells treated with Dexamethasone. Caused ~35% increase in cell proliferation rate for 1242-MG cells treated with Dexamethasone.

体内研究

Rasagiline is neuroprotective in a transgenic model of multiple system atrophy. Motor behavioural tests show improvements in motor deficits associated with 2.5 mg/kg Rasagiline therapy.

Animal Model:	(PLP)-α-synuclein transgenic mice over 6 months of age
Dosage:	Low-(0.8 mg/kg b.w.) and high dose (2.5 mg/kg b. w.)
Administration:	Administered subcutaneously every 24 h for a total period of 4 weeks (from day 1 till day 28 of the experiment).
Result:	Low dose treatment did not show protective efficacy in striatum with number of neurons similar to placebo treated MSA mice. High dose was associated with about 15% rescue of DARPP-32 immunoreactive striatal neurons. Low dose treatment had no effect on nigral neuronal loss, but high dose completely protected nigral neurons with numbers comparable to healthy controls.

分子式

C₁₂H₁₃N^.CH₄O₃S

分子量

267.34

CAS号

161735-79-1

中文名称

雷沙吉兰甲磺酸；甲磺酸雷沙吉兰

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : 25 mg/mL (93.51 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7406 mL	18.7028 mL	37.4056 mL
5 mM	0.7481 mL	3.7406 mL	7.4811 mL
10 mM	0.3741 mL	1.8703 mL	3.7406 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

临床试验

科研文献

纯度： 98%

Data Sheet

产品使用指南

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2

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Other Forms of Rapamycin:

KKL 顾客使用本产品发表的 2 篇科研文献

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