Myelin Basic Protein (87-99)
目录号 : KG12492 CAS No. : 118506-26-6 纯度 : 98%
The basic protein is a major structural protein of the central nervous system myelin in which it constitutes 30% of the total protein. T lymphocyte cell lines selected with whole MBP typically recognize only 1-3 immunodominant epitopes (Offner et al., 1987, 1988; Trotter et al., 1987: Bourdctte et al. 1988; McCarron and McFarlin, 1988) and these immunodominant MBP epitopes frequently are cncephalitogenic (Vandenbark et al., 1985b, 1989; Hashim et al., 1991). Thus, the identification of immunodominant MBP epitopes is likely to provide an in vitro method of identifying unrecognized enccphalitogenic epitopes of MBP. Although the cause of multiple sclerosis (MS) is not known, a T cell-mediated autoimmune process has been postulated. Myelin basic protein (MBP) is a potential target antigen because it induces experimental allergic encephalomyelitis (EAE) in susceptible animals. Encephalitogenic epitopes of MBP differ among susceptible strains and correlate with the MHC class II genotype.
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分子式
C74H114N20O17
分子量
1555.8
CAS号
118506-26-6
中文名称
Myelin Basic Protein (87-99)
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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