Azatadine - CAS:3964-81-6

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Azatadine (Synonyms:6,11-二氢-11-(1-甲基-4-哌啶亚基)-5H-苯并[5,6]环庚烷并[1,2-b]吡啶;阿扎他定;马来酸阿扎他啶)

目录号 : KG12343 CAS No. : 3964-81-6 纯度 : 98%

Data Sheet SDS 产品使用指南

Azatadine is an histamine and cholinergic inhibitor with IC50 of 6.5 nM and 10 nM, respectively.Target: Histamine ReceptorAzatadine, a new antihistamine, was evaluated for its efficacy in 20 patients with chronic allergic rhinitis. Eighty percent of patients had symptomatic relief with a twice daily dosage of 2 mg. Sedation was volunteered as a side effect by six of the patients and was admitted by two further patients after specific questioning. A choice reaction time test gave slowing of motor function in these sedated patients. Four of the previously sedated patients experienced good symptomatic control with minimal sedation when the azatadine dose was reduced to 1 mg twice daily; slowing of motor function was not observed at this, the normal recommended dose.Azatadine delays the onset of dyspnea-induced by aerosolized histamine, acetylcholine and serotonin in the conscious guinea-pig with PD50 of 0.01 mg/kg, 0.739 mg/kg and 0.86 mg/kg. Azatadine protects conscious guinea-pigs against death induced by the intravenous injection of histamine with oral PD50 of 0.009 mg/kg in guinea-pig and 0.22 mg/kg in mice.

规格	价格	是否有货	数量
5mg		In-stock	立即试用
20mg		In-stock

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分子式

C₂₀H₂₂N₂

分子量

290.4

CAS号

3964-81-6

中文名称

马来酸阿扎他啶

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

SDS

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

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动物实验计算换算器