2-Aminotetralin is a neuromodulatory agent.It inhibits serotonin (5-HT) and norepinephrine reuptake in rat brain when administered at a dose of 39.4 mg/kg. 2-Aminotetralin induces hypothermia in rats when administered by intracisternal or intraperitoneal injection, but implantation of 2-aminotetralin crystals in the medial preoptic area of the hypothalamus induces hyperthermia in rats. It substitutes for (+)-amphetamine in rats in a two-lever drug discrimination test in a dose-dependent manner.