1-(3-Chlorophenyl)biguanide (hydrochloride) (Synonyms:1-(3-氯苯基)双胍盐酸盐;1-(3-氯苯基)双胍;1-(3-氯苯基)双胍 盐酸盐)
目录号 : KG12294 CAS No. : 2113-05-5 纯度 : >95%
1-(3-Chlorophenyl)biguanide (m-CPBG) is an agonist of the serotonin (5-HT) receptor subtype 5-HT3.It selectively binds 5-HT3 over 5-HT1A and 5-HT2 receptors (Kis = 0.002, 10, and 10 µM, respectively) but also binds to high and low affinity sites on the dopamine transporter (DAT; IC50s = 0.4 and 34.8 µM, respectively, in rat caudate putamen synaptosomal membranes). m-CPBG induces depolarization of isolated rat vagus nerve and stimulates inositol phosphate formation in rat frontocingulate cortical slices (EC50s = 0.05 and 4.2 µM, respectively). It induces bradycardia, an effect that can be reversed by the 5-HT3 receptor antagonist ondansetron, in anaesthetized cats (ED50 = 20.3 nmol/kg).
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分子式
C8H10ClN5.HCl
分子量
248.1
CAS号
2113-05-5
中文名称
1-(3-氯苯基)双胍盐酸盐
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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