(+)-AJ 76 hydrochloride - CAS:85379-09-5

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(+)-AJ 76 hydrochloride (Synonyms:(1S,2R)-顺-5-甲氧基-1-甲基-2-(N-丙胺)萘满盐酸盐)

目录号 : KG12270 CAS No. : 85379-09-5 纯度 : 98%

Data Sheet 产品使用指南

(+)-AJ 76 hydrochloride is an antagonist of dopamine autoreceptor with pKi values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hD3, hD4, hD2S, hD2L and rD2 receptors, respectively. Dopamine receptor is a G protein-coupled receptor and mainly exists in the vertebrate central nervous system (CNS). Dopamine receptor is a receptor for dopamine and plays a critical role in memory, learning, pleasure, cognition, motivation and fine motor control. (+)-AJ 76 hydrochloride is a dopamine receptor antagonist. In rats, AJ76 stimulated locomotor activity and increased the levels of 3,4-dihydroxyphenylacetic acid (DOPAC) and HVA in brain, which were dopamine metabolites . In rats injected with cocaine, (+)-A J76 increased the locomotor stimulation during the first 30 min. However, (+)-AJ76 inhibited the later more intense locomotor stimulation and cocaine-induced stereotypies . In vivo, (+)-AJ76 induced dopamine release mainly through interaction with dopamine receptors in the terminal regions of the A9 and A10 dopaminergic fibers. However, (+)-AJ76 increased the level of DOPAC via the somatodendritic autoreceptors .

规格	价格	是否有货	数量
10mg		In-stock
50mg		In-stock

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分子式

C₁₅H₂₃NO^.HCl

分子量

269.81

CAS号

85379-09-5

中文名称

(1S,2R)-顺-5-甲氧基-1-甲基-2-(N-丙胺)萘满盐酸盐

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

纯度： 98%

Data Sheet

产品使用指南

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，注：如该浓度超过该批次药物DMSO溶解度，请先联系客服）；

体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL ddH₂O，混匀澄清。

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注意：1. 首先保证母液是澄清的；
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动物实验计算换算器