3-Hydroxy agomelatine - CAS:166526-99-4

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3-Hydroxy agomelatine

目录号 : KM7306 CAS No. : 166526-99-4

Data Sheet 产品使用指南

3-Hydroxy agomelatine 是 Agomelatine 的代谢产物。3-Hydroxy agomelatine 是 5-HT_2C 受体拮抗剂，IC₅₀ 为 3.2 μM，K_i 为 1.8 μM。

规格	价格	是否有货	数量
5mg		In-stock

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生物活性	3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT_2C receptor antagonist with an IC₅₀ of 3.2 μM and a K_i of 1.8 μM.
体外研究	Agomelatine and S 21517 have moderately high affinities for 5-HT_2C receptors (K_i = 0.21 μM and 0.13 μM, respectively). The metabolite 3-Hydroxy agomelatine (S 21540) has a 10-fold lower affinity (K_i = 1.8 μM). Agomelatine, S 21517 and 3-Hydroxy agomelatine (10-10 M) are antagonists at 5-HT_2C receptors, with a rank order of efficacy as follows: S 21517>Agomelatine>3-Hydroxy agomelatine.
体内研究	Increasing doses (from 1.25 to 40 mg/kg, intraperitoneal injection) of 3-Hydroxy agomelatine (S 21540) does not affect the penile erections induced by mCPP and Ro 60-0175 in Wistar rat.
分子式	C₁₅H₁₇NO₃
分子量	259.30
CAS号	166526-99-4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.