Hydroxy Bupropion (Synonyms:羟基1-(3-氯苯基)-2-[(1,1-二甲基乙基)氨基]-1-丙酮盐酸盐;羟基丁螺环酮;安非他酮吗啉;羟基安非他酮,立体异构体混合物;2-羟基-2-(3-氯苯基)-3,5,5-三甲基吗啉)
目录号 : KG11625 CAS No. : 357399-43-0 纯度 : 98%
Buproprion is an inhibitor of the reuptake of dopamine and norepinephrine and is also an antagonist of neuronal acetylcholine nicotinic receptors. Because of its effects on nicotinic receptors, it is used to promote smoking cessation. Hydroxy bupropion is a mixture of enantiomers produced by the metabolism of buproprion by cytochrome P450 2B6. Compared with buproprion, this racemic mixture produces equal inhibition of norepinephrine reuptake (IC50 = 1.7 µM) and much weaker inhibition of dopamine reuptake (IC50 >10 µM). Moreover, hydroxyl bupropion isomers are potent antagonists of nicotinic receptors, suggesting that they may substitute for bupropion in smoking cessation.
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分子式
C13H18ClNO2
分子量
255.7
CAS号
357399-43-0
中文名称
羟基丁螺环酮
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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