Doxazosin (Synonyms:多沙唑嗪;奈夫西林;乙氧苯青霉素;1-(4-氨基-6,7-二甲氧基-2-喹唑啉基)-4-[(2,3-二氢-1,4-苯并二噁烷-2-基)羰基]哌嗪;4-氨基-2-[4-(1,4-苯并二嘿烷-2-羰基)哌嗪-1-基]-6,7-二甲氧基喹唑啉;多沙唑嗪 标准品;多沙唑嗪(甲磺酸多沙唑嗪);甲磺酸多沙唑嗪;甲磺酸多沙唑嗪杂质;多沙唑嗪,盐酸D8)
目录号 : KG11541 CAS No. : 74191-85-8 纯度 : 98%
Doxazosin (UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors. Doxazosin(UK 33274) is a long-lasting inhibitor of α1-adrenoceptors that is widely used to treat benign prostatic hyperplasia and lower urinary tract symptoms. doxazosin may have a direct inhibitory effect on cholesterol synthesis independent of the LDL receptor. The inhibition of cholesterol synthesis by doxazosin may cause cells to compensate by upregulating the LDL receptor, thereby increasing the importation of lipoprotein cholesterol and reducing LDL cholesterol in the medium. Doxazosin monotherapy was effective in eight of 12 patients (66.7%), and combined therapy with a beta-blocker was effective in 11 of 12 patients (91.7%). The mean pulse rate remained constant throughout therapy. Adverse reactions were minor and transient and occurred in only three patients. Urinary and plasma catecholamine levels tended to decrease or remained unchanged during doxazosin therapy.
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50mg
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100mg
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分子式
C23H25N5O5
分子量
451.48
CAS号
74191-85-8
中文名称
多沙唑嗪
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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