Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively.
IC50&Target
IC50: 0.25 nM (GnRHR)
Ki: 3.7 nM (GnRHR)
体外研究
Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with an IC50 of 0.25 nM in Kinase assay. Elagolix sodium has advanced to phase 3 trials for the treatment of endometriosis and uterine fibroids. Elagolix sodium also shows NFAT inhibition with an IC50 of 5.4 nM and effectively blocks Ca flux with an IC50 of 0.86 nM. Kinase assay also demonstrates that Elagolix sodium is a human GnRH receptor (GnRHR) antagonist with a Ki value of 3.7 nM.
分子式
C32H29N3O5F5-.Na+
分子量
653.57
CAS号
832720-36-2
中文名称
恶拉戈利钠盐
运输条件
Room temperature in continental US; may vary elsewhere.