Teicoplanin A2-2 (Synonyms:替考拉宁;替考拉宁 A2-2;替考拉宁A2)
目录号 : KG11142 CAS No. : 91032-26-7 纯度 : 98%
Teicoplanin A2-2 is a new glycopeptide antibiotic belonging to the same family as vancomycin. Teicoplanin consists of five major components (A2-1 through A2-5), one hydrolysis component (A3-1), and four minor components (RS-1 through RS-4) . Teicoplanin is isolated from the fermentation broth of Actinoplanes teichomyceticus nov. sp. and has been endowed with outstanding bactericidal activity against grampositive pathogenic bacteria . In vitro: Teicoplanin inhibited cell wall synthesis in Bacillus subtilis, the inhibition is accompanied by an intracellular accumulation of UDP-N-acetyl-muramyl-pentapeptide. In a cell-free system from Bacillus stearothermophilus, treatment with teicoplanin (40 μg/ml) inhibited 50% of peptidoglycan synthesis, and 100 μg/ml teicoplanin totally suppressed peptidoglycan synthesis . In vivo: Following intravenous administration, concentrations of teicoplanin were high in lung and bone tissue and low in fat in relative to those in plasma in patients with normal renal function. Animal data showed high concentrations in most tissues, and particularly high in liver and kidneys .
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分子式
C88H97Cl2N9O33
分子量
1879.7
CAS号
91032-26-7
中文名称
替考拉宁A2
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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