TJ-M2010-5 - CAS:1357471-57-8

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TJ-M2010-5

目录号 : KM7181 CAS No. : 1357471-57-8 纯度 : 98%

Data Sheet 产品使用指南

TJ-M2010-5 是一种 MyD88 抑制剂，可与 MyD88 的 TIR 结构域结合以干扰其同源二聚化和 TLR/MyD88 信号通路。TJ-M2010-5 可用于心肌缺血/再灌注损伤（MIRI）的研究。

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10mg		In-stock
25mg		In-stock
50mg		In-stock
100mg		In-stock
200mg	询价	In-stock
500mg	询价	In-stock

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Other Forms of Rapamycin:

KKL Med 的所有产品和服务仅用于科学研究，不能被用于人体，兽医，我们也不向个人提供产品和服务。

生物活性

TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain of MyD88 to interfere with its homodimerization, and the TLR/MyD88 signal pathway. TJ-M2010-5 can be used for the research of myocardial ischemia/reperfusion injury (MIRI).

体外研究

TJ-M2010-5 (40 µM) inhibits MyD88 homodimerization in transfected HEK293 cells in a concentration-dependent manner and suppresses MyD88 signaling in LPS (100 ng/mL)-responsive RAW 264.7 cells in vitro.
TJ-M2010-5 (5-30 μM) prevents B cell proliferation and induces B cells apoptosis after stimulation with R848 (500 ng/mL).

Cell Viability Assay

Cell Line:	Purified B cells
Concentration:	0 μM, 5 μM, 10 μM, 20 μM and 30 μM
Incubation Time:	48 hours
Result:	Inhibited the viability of B cells with or without the stimulation of CD40L.

体内研究

TJ-M2010-5 treatment statistically significantly reduces AOM/DSS-induced colitis and completely prevented CAC development with less related body mass loss, results in 0% mortality of treated mice, decreases cell proliferation, and increased apoptosis in colon tissue in a 10-week CAC mouse model.
TJ-M2010-5 statistically significantly decreases TNF-α, IL-6, G-CSF, MIP-1β, IL-11, IL-17A, IL-22, and IL-23 serum concentrations in mice at both two and seven weeks postinduction, as well as TGF-β1 serum levels at seven weeks postinduction.

Animal Model:	Female BalB/c mice (6–8 weeks old)
Dosage:	50 mg/kg
Administration:	Treated i.p. daily beginning two days before the first dextran sodium sulfate (DSS) administration throughout a 10-week observation period.
Result:	Significantly prevented inflammation/CAC-related body weight loss and mortality (0% vs 53% in the control group).

分子式

C₂₃H₂₆N₄Os

分子量

406.54

CAS号

1357471-57-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (245.98 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4598 mL	12.2989 mL	24.5978 mL
5 mM	0.4920 mL	2.4598 mL	4.9196 mL
10 mM	0.2460 mL	1.2299 mL	2.4598 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

纯度： 98%