ZK-261991
(Synonyms:ZK-261991)
目录号 : KG10851
CAS No. : 886563-25-3
纯度 : 98%
ZK-261991 is an orally active VEGFR tyrosine kinase inhibitor with an IC50 of 5 nM for VEGFR2.
ZK-261991 inhibits cellular receptor autophosphorylation in KDR-PAECs with an IC50 of 2 nM. ZK991 inhibits VEGFR-3 autophosphorylation concentration dependently with an IC50 of 20 nM.
ZK991 results in a significantly reduced recruitment of CD11b+ and LYVE-1+ cells into the murine cornea. ZK991 significantly improves the graft survival rate after corneal transplantation.
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| 分子式 |
C24H25N7O2
|
| 分子量 |
443.5
|
| CAS号 |
886563-25-3
|
| 中文名称 |
ZK-261991
|
| 储存方式 |
| Powder |
-20°C |
3 years |
| |
4°C |
2 years |
| In solvent |
-80°C |
6 months |
| |
-20°C |
1 month |
|