Istaroxime hydrochloride is a Na/K-ATPase inhibitor (IC50=0.11 μM) and a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
IC50&Target
IC50: 0.11 μM (Na,K-ATPase)
体外研究
Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na,K-ATPase. Istaroxime (PST2744) inhibits the Na/K-ATPase activity from dog kidney with an IC50 value of 0.43 ± 0.15 μM. Inhibition of Na/K-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.
体内研究
Istaroxime (PST2744) induces a progressive increase in +dP/dtmax throughout the infusion that reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg.
分子式
C21H33ClN2O3
分子量
396.95
CAS号
374559-48-5
运输条件
Room temperature in continental US; may vary elsewhere.