DTPA is a cell-impermeable metal chelating agent. It chelates copper, iron, zinc, and manganese, as well as calcium, magnesium, and plutonium. DTPA has been used as a metal chelating agent in the study of ferroptosis. It reduces the skeletal plutonium burden and incidence of bone tumors, as well as increases survival in a mouse model of intravenous plutonium exposure when administered at a dose of 500 mg/kg. Formulations containing DTPA conjugated to radioactive compounds have been used as diagnostic agents for brain imaging, renal visualization, and lung imaging.