Belinostat (PXD101) (Synonyms:Belinostat (PXD101) 抑制剂;Belinostat 贝利司他(PXD101);N-羟基-3-(3-(N--苯基氨磺酰基)苯基)丙烯酰胺;N-羟基-3-(3-苯基氨基磺酰基苯基)丙烯酰胺;贝利司他;贝利司他(PXD101);贝利司他杂质;贝利斯他;苯林若斯特)
目录号 : KG10407 CAS No. : 414864-00-9 纯度 : 98%
Belinostat (also known as PXD101) is a novel and potent hydroxamate-type inhibitor of histone deacetylase (HDAC) that inhibits the activity of HDAC in Hela cell extracts with 50% inhibition concentration IC50 value of 27 nM. Belinostat has been found to significantly increase the acetylation of histones H3 and H4 and exerts cytotoxicity in a wide range of tumor cell lines. In the treatment of urothelial carcinoma cell lines, belinostat dose-dependently inhibits proliferation in 5637, T24, J82 and RT4 cells with IC50 values of 1.0 μM, 3.5 μM, 6.0 μM and 10 μM respectively; while, in prostate cancer cell lines, it inhibits cancer cell growth with IC50 values ranging from 0.5 to 2.5 μM.
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Other Forms of Rapamycin:

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分子式
C15H14N2O4S
分子量
318.35
CAS号
414864-00-9
中文名称
苯林若斯特
储存方式
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
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