Indium (III) thiosemicarbazone 5b
目录号 : KG10328
CAS No. : 2345755-20-4
纯度 : >95%
Indium (III) thiosemicarbazone 5b is an anticancer agent.It is cytotoxic to A549, MCF-7 breast, MCF-7/DDP cisplatin-resistant breast, and Hl 7702 liver cancer cells (IC50s = 2.41, 1.97, 2.11, and 8.95 µM, respectively). Indium (III) thiosemicarbazone 5b decreases PI3K, Akt, mTOR, P-gp, and GSH levels in MCF-7/DDP cells. In vivo, indium (III) thiosemicarbazone 5b (2.5 µmol/kg) reduces tumor weight and volume in an MCF-7/DDP mouse xenograft model. Liposomes containing indium (III) thiosemicarbazone 5b also induce apoptosis and pro-death autophagy in MCF-7/DDP cells, as well as reduce tumor volume and weight in an MCF-7/DDP mouse xenograft model.
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分子式 |
C10H15Cl2InN4Os
|
分子量 |
425
|
CAS号 |
2345755-20-4
|
储存方式 |
-20°C
|