Cl-Necrostatin-1
目录号 : KG10313
CAS No. : 862377-51-3
纯度 : >95%
Cl-Necrostatin-1 is an inhibitor of receptor-interacting protein kinase 1 (RIPK1). It inhibits RIPK1 activity when used at concentrations of 0.3, 3, and 30 µM. It also inhibits TNF-α-induced necroptosis in Jurkat cells deficient in Fas-associated death domain protein (FADD; EC50 = 180 nM), a modification that prevents caspase activation in response to death-domain receptor signaling. Cl-Necrostatin-1 (2 µl of a 4 mM solution, i.c.v.) reduces infarct size when administered pre- and post-occlusion, or post-occlusion only, in a mouse model of middle cerebral artery occlusion (MCAO).
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| 分子式 |
C13H12ClN3Os
|
| 分子量 |
293.8
|
| CAS号 |
862377-51-3
|
| 储存方式 |
-20°C
|
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Data Sheet
