H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC50 of 5 μM. Antihypertensive tripeptides.
Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs).
Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated ratsIle-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) .Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice.